Microsoft Word - manuscript rev2 v2

نویسندگان

  • Basir Ahmad
  • Lisa J. Lapidus
چکیده

Background: -synuclein is an aggregation-prone protein which reconfigures more slowly under aggregating conditions. Results: Curcumin binds to monomeric synuclein, prevents aggregation and increases the reconfiguration rate, particularly at high temperatures. Conclusion: Curcumin rescues the protein from aggregation by making the protein more diffusive. Significance: The search for aggregation inhibitors should account for changes in chain dynamics by the small molecule.

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تاریخ انتشار 2012